LINC00667/miR-449b-5p/YY1 axis promotes cell proliferation and migration in colorectal cancer.

ABSTRACT:

Background

Long non-coding RNAs (lncRNAs) have been defined as vital regulators in the progression of human cancers, including colorectal cancer (CRC). Long intergenic non-protein coding RNA 667 (LINC00667) is a tumor promoter in several cancer types, while its role in CRC remains to be unmasked. This study focused on exploring the potential function and regulatory mechanism of LINC00667 in CRC.

Methods

qRT-PCR analysis was applied to detect the expression of LINC00667 in CRC cells. Loss-of function assays revealed the role of LINC00667 silencing in regulating CRC cell proliferation, apoptosis and migration. In vivo study demonstrated the effect of LINC00667 silencing on CRC cell growth. Mechanism experiments were conducted to determine the upstream or the downstream molecul

SUBMITTER: Yu J 

PROVIDER: S-EPMC7368754 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature