Clinical and histological significance of urinary CD11c⁺ macrophages in lupus nephritis.

ABSTRACT:

Background

Infiltration of immune cells into the kidney is one of the key features of lupus nephritis (LN). The presence of immune cells in the urine may be used as a non-invasive biomarker of LN. Here, we aimed to analyze the clinicopathologic significance of urinary CD11c⁺ macrophages in patients with LN.

Methods

The numbers and proportions of CD11c⁺ macrophages in the urine samples of patients with LN at the time of kidney biopsy were examined using flow cytometry. We also examined the association between the levels of urinary CD11c⁺ macrophages and the clinical and pathologic features of patients with LN.

Results

Compared with patients without LN or those with non-proliferative LN, patients with proliferative LN had significantly h

SUBMITTER: Kim J 

PROVIDER: S-EPMC7368794 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature