ERK and Akt exhibit distinct signaling responses following stimulation by pro-angiogenic factors.

ABSTRACT:

Background

Angiogenesis plays an important role in the survival of tissues, as blood vessels provide oxygen and nutrients required by the resident cells. Thus, targeting angiogenesis is a prominent strategy in many different settings, including both tissue engineering and cancer treatment. However, not all of the approaches that modulate angiogenesis lead to successful outcomes. Angiogenesis-based therapies primarily target pro-angiogenic factors such as vascular endothelial growth factor-A (VEGF) or fibroblast growth factor (FGF) in isolation, and there is a limited understanding of how these promoters combine together to stimulate angiogenesis. Targeting one pathway could be insufficient, as alternative pathways may compensate, diminishing the overall effect of the treatment stra

SUBMITTER: Song M 

PROVIDER: S-EPMC7368799 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature