Relationships Between Plasma Lipids Species, Gender, Risk Factors, and Alzheimer's Disease.

ABSTRACT:

Background

Lipid metabolism is altered in Alzheimer's disease (AD); however, the relationship between AD risk factors (age, APOEɛ4, and gender) and lipid metabolism is not well defined.

Objective

We investigated whether altered lipid metabolism associated with increased age, gender, and APOE status may contribute to the development of AD by examining these risk factors in healthy controls and also clinically diagnosed AD individuals.

Methods

We performed plasma lipidomic profiling (582 lipid species) of the Australian Imaging, Biomarkers and Lifestyle flagship study of aging cohort (AIBL) using liquid chromatography-mass spectrometry. Linear regression and interaction analysis were used to explore the relationship between risk factors and plasma lipid species.

Resu

SUBMITTER: Lim WLF 

PROVIDER: S-EPMC7369125 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature