Nodal positivity decreases with age in women with early-stage, hormone receptor-positive breast cancer.

ABSTRACT:

Background

Despite data demonstrating the safety of omitting axillary surgery in older women with early-stage breast cancer, the incidence of axillary surgery remains high. It was hypothesized that the prevalence of nodal positivity would decrease with advancing age.

Methods

The National Cancer Data Base was used to construct a cohort of adult women with early-stage, clinically node-negative, estrogen receptor-positive (ER+), human epidermal growth factor receptor 2-negative breast cancer treated between 2013 and 2015. Multivariable logistic regression was used to assess the relationship between age and nodal positivity, and this was stratified by the axillary surgery category. Modified Poisson regression was used to estimate the proportion of women receiving adjuvant therap

SUBMITTER: Downs-Canner SM 

PROVIDER: S-EPMC7369168 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature