High Psychopathology Subgroup in Young Children With Autism: Associations With Biological Sex and Amygdala Volume.

ABSTRACT:

Objective

The aims of this study were to identify a subset of children with autism spectrum disorder (ASD) and co-occurring symptoms of psychopathology, and to evaluate associations between this subgroup and biological sex and amygdala volume.

Method

Participants included 420 children (ASD: 91 girls, 209 boys; typically developing controls: 57 girls, 63 boys). Latent profile analysis was used to identify ASD subgroups based on symptoms of psychopathology, adaptive functioning, cognitive development, and autism severity. Differences in the proportions of girls and boys across subgroups were evaluated. Magnetic resonance imaging scans were acquired (346 children); amygdala volumes were evaluated in relation to subgroups and problem behavior scores.

Results

Three ASD sub

SUBMITTER: Nordahl CW 

PROVIDER: S-EPMC7369216 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature