Insights into the genetic basis of HMGB1 in atrial fibrillation in a Chinese Han population.

ABSTRACT:

Background

Atrial fibrillation (AF) is the most common cardiac arrhythmia. High mobility group box 1 (HMGB1) has been demonstrated to be involved in AF, but the genetic relationship between them is not clear yet. Here, we investigated the genetic association between functional variants in HMGB1 and AF in a Chinese Han population.

Methods

Two common variants (the promoter one rs1045411^T/C and the 3'UTR one rs1412125^C/T) in HMGB1 were selected and genotyped in 576 AF patients and 869 control subjects. Traditional risk factors, such as age, gender, the history of smoking, hypertension and diabetes mellitus, were adjusted as covariates using a logistic regression analysis (SPSS, v.21.0). The haplotypic analysis was performed using SPSS (v.21.0

SUBMITTER: Li L 

PROVIDER: S-EPMC7369288 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature