Second career of a biosynthetic enzyme: Lumazine synthase as a virus-like nanoparticle in vaccine development.

ABSTRACT: Naturally occurring and computationally ab initio designed protein cages can now be considered as extremely suitable materials for new developments in nanotechnology. Via self-assembly from single identical or non-identical protomers large oligomeric particles can be formed. Virus-like particles have today found a number of quite successful applications in the development of new vaccines. Complex chimeric nanoparticles can serve as suitable platforms for the presentation of natural or designed antigens to the immune system of the host. The scaffolds can be cage forming highly symmetric biological macromolecules like lumazine synthase or symmetric self-assembling virus-like particles generated by computational ab initio design. Symmetric nanoparticle carriers display a structu

SUBMITTER: Ladenstein R 

PROVIDER: S-EPMC7369331 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature