Elevated mRNA Expression Levels of NCAPG are Associated with Poor Prognosis in Ovarian Cancer.

ABSTRACT:

Background

Ovarian cancer is a major gynecologic malignancy that is often detected at a late stage due to the lack of detailed studies on its pathogenesis and reliable biomarkers for predicting its prognosis.

Materials and methods

Four ovarian cancer data sets GSE18520, GSE27651, GSE40595, and GSE52037 were downloaded from the Gene Expression Omnibus (GEO) database and the robust rank aggregation approach was used to find common differentially expressed genes (DEGs). Cytoscape software was used to construct and detect key models of protein-protein interaction (PPI) network. While the expression, prognostic value and potential mechanism of the hub gene non-SMC condensin I complex subunit G (NCAPG) was carried out through Gene Expression Profiling Interactive Analysis, Kaplan-

SUBMITTER: Xu T 

PROVIDER: S-EPMC7369365 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature