Human Serum Albumin in the Presence of AGuIX Nanoagents: Structure Stabilisation without Direct Interaction.

ABSTRACT: The gadolinium-based nanoagent named AGuIX^® is a unique radiosensitizer and contrast agent which improves the performance of radiotherapy and medical imaging. Currently tested in clinical trials, AGuIX^® is administrated to patients via intravenous injection. The presence of nanoparticles in the blood stream may induce harmful effects due to undesired interactions with blood components. Thus, there is an emerging need to understand the impact of these nanoagents when meeting blood proteins. In this work, the influence of nanoagents on the structure and stability of the most abundant blood protein, human serum albumin, is presented. Synchrotron radiation circular dichroism showed that AGuIX^® does not bind to the protein, even at the high ratio of 45 nanoparti

SUBMITTER: Yang X 

PROVIDER: S-EPMC7369717 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature