Cell-Fate Determination from Embryo to Cancer Development: Genomic Mechanism Elucidated.

ABSTRACT: Elucidation of the genomic mechanism that guides the cell-fate change is one of the fundamental issues of biology. We previously demonstrated that whole genome expression is coordinated by the emergence of a critical point at both the cell-population and single-cell levels through the physical principle of self-organized criticality. In this paper, we further examine the genomic mechanism that determines the cell-fate changes from embryo to cancer development. The state of the critical point, acting as the organizing center of the cell fate, determines whether the genome resides in a super- or sub-critical state. In the super-critical state, a specific stochastic perturbation can spread over the entire system through the "genome engine", an autonomous critical-control genomic system, where

SUBMITTER: Tsuchiya M 

PROVIDER: S-EPMC7369777 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature