Systemic Investigation of Promoter-wide Methylome and Genome Variations in Gout.

ABSTRACT: Current knowledge of gout centers on hyperuricemia. Relatively little is known regarding the pathogenesis of gouty inflammation. To investigate the epigenetic background of gouty inflammation independent of hyperuricemia and its relationship to genetics, 69 gout patients and 1455 non-gout controls were included. Promoter-wide methylation was profiled with EPIC array. Whole-genome sequencing data were included for genetic and methylation quantitative trait loci (meQTL) analyses and causal inference tests. Identified loci were subjected to co-methylation analysis and functional localization with DNase hypersensitivity and histone marks analysis. An expression database was queried to clarify biologic functions of identified loci. A transcription factor dataset was integrated to identify trans

SUBMITTER: Tseng CC 

PROVIDER: S-EPMC7369819 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature