Lipidomic Biomarkers in Polycystic Ovary Syndrome and Endometrial Cancer.

ABSTRACT: Women with polycystic ovary syndrome (PCOS) are more likely to develop endometrial cancer (EC). The molecular mechanisms which increase the risk of EC in PCOS are unclear. Derangements in lipid metabolism are associated with EC, but there have been no studies, investigating if this might increase the risk of EC in PCOS. This was a cross-sectional study of 102 women in three groups of 34 (PCOS, EC and controls) at Nottingham University Hospital, UK. All participants had clinical assessments, followed by obtaining plasma and endometrial tissue samples. Lipidomic analyses were performed using liquid chromatography (LC) coupled with high resolution mass spectrometry (HRMS) and the obtained lipid datasets were screened using standard software and databases. Using multivariate data analysis, the

SUBMITTER: Shafiee MN 

PROVIDER: S-EPMC7370092 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature