Vimentin as a Multifaceted Player and Potential Therapeutic Target in Viral Infections.

ABSTRACT: Vimentin is an intermediate filament protein that plays key roles in integration of cytoskeletal functions, and therefore in basic cellular processes such as cell division and migration. Consequently, vimentin has complex implications in pathophysiology. Vimentin is required for a proper immune response, but it can also act as an autoantigen in autoimmune diseases or as a damage signal. Although vimentin is a predominantly cytoplasmic protein, it can also appear at extracellular locations, either in a secreted form or at the surface of numerous cell types, often in relation to cell activation, inflammation, injury or senescence. Cell surface targeting of vimentin appears to associate with the occurrence of certain posttranslational modifications, such as phosphorylation and/or oxidative da

SUBMITTER: Ramos I 

PROVIDER: S-EPMC7370124 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature