Oocyte competence is maintained by m⁶A methyltransferase KIAA1429-mediated RNA metabolism during mouse follicular development.

ABSTRACT: KIAA1429 (also known as vir-like m⁶A methyltransferase-associated protein (VIRMA)), a newly identified component of the RNA m⁶A methyltransferase complex, plays critical roles in guiding region-selective m⁶A deposition. However, in mammals, whether KIAA1429 mediates RNA m⁶A regulatory pathway functions in vivo remains unknown. Here, we show that the Kiaa1429-specific deficiency in oocytes resulted in female infertility with defective follicular development and fully grown germinal vesicle (GV) oocytes failing to undergo germinal vesicle breakdown (GVBD) and consequently losing the ability to resume meiosis. The oocyte growth is accompanied by the accumulation of abundant RNAs and posttranscriptional regulation. We found that the loss of Kiaa1429

SUBMITTER: Hu Y 

PROVIDER: S-EPMC7370231 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature