Adaptive in vivo device for theranostics of inflammation: Real-time monitoring of interferon-γ and aspirin.

ABSTRACT: Cytokines mediate and control immune and inflammatory responses. Complex interactions exist among cytokines, inflammation, and the innate and adaptive immune responses in maintaining homeostasis, health, and well-being. On-demand, local delivery of anti-inflammatory drugs to target tissues provides an approach for more effective drug dosing while reducing the adverse effects of systemic drug delivery. This work demonstrates a proof-of-concept theranostic approach for inflammation based on analyte-kissing induced signaling, whereby a drug (in this report, aspirin) can be released upon the detection of a target level of a proinflammatory cytokine (i.e., interferon-γ (IFN-γ)) in real time. The structure-switching aptamer-based biosensor described here is capable of quantitatively and dynamica

SUBMITTER: Cao C 

PROVIDER: S-EPMC7370241 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature