Risk factors for non-adherence to disease-modifying therapy in pediatric multiple sclerosis.

ABSTRACT:

Background

Adherence to disease-modifying therapies (DMTs) in pediatric multiple sclerosis (MS) is not well understood. We examined the prevalence and risk factors for poor adherence in pediatric MS.

Methods

This cross-sectional study recruited youth with MS from 12 North American pediatric MS clinics. In addition to pharmacy-refill data, patients and parents completed self-report measures of adherence and quality of life. Additionally, patients completed measures of self-efficacy and well-being. Factor analysis and linear regression methods were used.

Results

A total of 66 youth (mean age, 15.7 years) received MS DMTs (33% oral, 66% injectable). Estimates of poor adherence (i.e. missing >20% of doses) varied by source: pharmacy 7%, parent 14%, and patient 41%. Factor

SUBMITTER: Schwartz CE 

PROVIDER: S-EPMC7370309 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature