Microvascular platelet aggregation and thrombosis after subarachnoid hemorrhage: A review and synthesis.

ABSTRACT: Delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (SAH) has been associated with numerous pathophysiological sequelae, including large artery vasospasm and microvascular thrombosis. The focus of this review is to provide an overview of experimental animal model studies and human autopsy studies that explore the temporal-spatial characterization and mechanism of microvascular platelet aggregation and thrombosis following SAH, as well as to critically assess experimental studies and clinical trials highlighting preventative therapeutic options against this highly morbid pathophysiological process. Upon review of the literature, we discovered that microvascular platelet aggregation and thrombosis occur after experimental SAH across multiple species and SAH induction tec

SUBMITTER: Clarke JV 

PROVIDER: S-EPMC7370365 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature