Comparison of simultaneous arterial spin labeling MRI and ¹⁵O-H₂O PET measurements of regional cerebral blood flow in rest and altered perfusion states.

ABSTRACT: Arterial spin labelling (ASL) is a non-invasive magnetic resonance imaging (MRI) technique that may provide fully quantitative regional cerebral blood flow (rCBF) images. However, before its application in clinical routine, ASL needs to be validated against the clinical gold standard, ¹⁵O-H₂O positron emission tomography (PET). We aimed to compare the two techniques by performing simultaneous quantitative ASL-MRI and ¹⁵O-H₂O-PET examinations in a hybrid PET/MRI scanner. Duplicate rCBF measurements were performed in healthy young subjects (n = 14) in rest, during hyperventilation, and after acetazolamide (post-ACZ), yielding 63 combined PET/MRI datasets in total. Average global CBF by ASL-MRI and ¹⁵O-H₂O-PET was not si

SUBMITTER: Puig O 

PROVIDER: S-EPMC7370368 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature