Lens placode planar cell polarity is dependent on Cdc42-mediated junctional contraction inhibition.

ABSTRACT: Development of the ocular lens commences with the formation of the lens placode, an epithelial structure that thickens and subsequently bends inward in a process called invagination. Invagination is observed during the development of many embryonic structures, but the spectrum of morphogenetic events driving this process are, in most cases, not fully understood. A characteristic commonly found in embryonic tissues undergoing epithelial reorganization is planar polarity, a property where cells are geometrically and/or molecularly orientated in a specific direction along the plane of an epithelium. Planar polarity is known to drive the morphogenesis of several epithelial structures, however its role during invagination events is less clear. We have found that at the onset of invagination, ce

SUBMITTER: Muccioli M 

PROVIDER: S-EPMC7370377 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature