World Trade Center Dust induces airway inflammation while promoting aortic endothelial dysfunction.

ABSTRACT: Respiratory ailments have plagued occupational and public health communities exposed to World Trade Center (WTC) dust since the September 11, 2001 attack on the Twin Towers in Lower Manhattan. We proposed that these ailments were proposed to be induced by inhalation exposure to WTC particulate matter (WTC_PM), that was released during the collapse of the buildings and its subsequent resuspension during cleanup. We investigated this hypothesis using both an in vitro and an in vivo mouse intranasal (IN) exposure models to identify the inflammatory potential of WTC_PM with specific emphasis on respiratory and endothelial tissue responses. The in vitro exposure studies found WTC_PM exposure to be positively correlated with cytotoxicity and increased NO₂

SUBMITTER: Hernandez M 

PROVIDER: S-EPMC7370403 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature