Ontology highlight
ABSTRACT:
SUBMITTER: Duggan AT
PROVIDER: S-EPMC7370420 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Duggan Ana T AT Klunk Jennifer J Porter Ashleigh F AF Dhody Anna N AN Hicks Robert R Smith Geoffrey L GL Humphreys Margaret M McCollum Andrea M AM Davidson Whitni B WB Wilkins Kimberly K Li Yu Y Burke Amanda A Polasky Hanna H Flanders Lowell L Poinar Debi D Raphenya Amogelang R AR Lau Tammy T Y TTY Alcock Brian B McArthur Andrew G AG Golding G Brian GB Holmes Edward C EC Poinar Hendrik N HN
Genome biology 20200720 1
Vaccination has transformed public health, most notably including the eradication of smallpox. Despite its profound historical importance, little is known of the origins and diversity of the viruses used in smallpox vaccination. Prior to the twentieth century, the method, source and origin of smallpox vaccinations remained unstandardised and opaque. We reconstruct and analyse viral vaccine genomes associated with smallpox vaccination from historical artefacts. Significantly, we recover viral mol ...[more]