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Early precursor T-cell acute lymphoblastic leukemia: current paradigms and evolving concepts.

ABSTRACT: Early precursor T cell-acute lymphoblastic leukemia (ETP-ALL) is a rare entity characterized by chemo-resistance and a paucity of data regarding optimal management. We review here the literature regarding the management of ETP-ALL and focus on the recent, emerging data, regarding the potential role of molecularly targeted approaches with a focus on venetoclax.

SUBMITTER: Castaneda Puglianini O 

PROVIDER: S-EPMC7370557 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Early precursor T-cell acute lymphoblastic leukemia: current paradigms and evolving concepts.

Castaneda Puglianini Omar O   Papadantonakis Nikolaos N  

Therapeutic advances in hematology 20200716

Early precursor T cell-acute lymphoblastic leukemia (ETP-ALL) is a rare entity characterized by chemo-resistance and a paucity of data regarding optimal management. We review here the literature regarding the management of ETP-ALL and focus on the recent, emerging data, regarding the potential role of molecularly targeted approaches with a focus on venetoclax. ...[more]

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