Polymorphism rs1801516 (G > A) in the ATM gene is not associated with overall cancer risk: an updated meta-analysis.

ABSTRACT:

Objective

The ataxia telangiectasia mutated (ATM) gene contains a functional single nucleotide polymorphism (SNP) rs1801516 (G > A) that may be associated with cancer risk. This meta-analysis aimed to interrogate the relationship between rs1801516 and cancer occurrence and disease etiology.

Methods

We retrieved and identified the available case-control studies that met the inclusion criteria from the PubMed, Web of Science, and Embase databases. Odds ratio (OR) and 95% confidence intervals (CIs) were used to measure the association between rs1801516 and cancer risk. Additionally, we performed sensitivity, subgroup, and publication bias analyses.

Results

After inclusion criteria were met, the meta-analysis included 29 studies, with 9,453 cancer patients (cases)

SUBMITTER: Li Y 

PROVIDER: S-EPMC7370572 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature