Longitudinal evaluation of surrogates of regional cerebral blood flow computed from dynamic amyloid PET imaging.

ABSTRACT: Surrogates of neuronal activity, typically measured by regional cerebral blood flow (rCBF) or glucose metabolism, can be estimated from dynamic amyloid PET imaging. Using data for 149 participants (345 visits) from the Baltimore Longitudinal Study of Aging, we assessed whether the average of early amyloid frames (EA) and R₁ computed from dynamic ¹¹C-Pittsburgh compound B (PiB) PET can serve as surrogates of rCBF computed from ¹⁵O-H₂O-PET. R₁ had the highest longitudinal test-retest reliability. Interquartile range (IQR) of cross-sectional Pearson correlations with rCBF was 0.60-0.72 for EA and 0.63-0.72 for R₁. Correlations between rates of change were lower (IQR 0.22-0.50 for EA, 0.25-0.55 for R<

SUBMITTER: Bilgel M 

PROVIDER: S-EPMC7370613 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature