Efficacy of local budesonide therapy in the management of persistent hyposmia in COVID-19 patients without signs of severity: A structured summary of a study protocol for a randomised controlled trial.

ABSTRACT:

Objectives

To assess the efficacy of local intranasal treatment with budesonide (nasal irrigation), in addition to olfactory rehabilitation, in the management of loss of smell in COVID-19 patients without signs of severity and with persistent hyposmia 30 days after the onset of symptoms. To search for an association between the presence of an obstruction on MRI and the severity of olfactory loss, at inclusion and after 30 days of treatment.

Trial design

Two center, open-label, 2-arm (1:1 ratio) parallel group randomized controlled superiority trial.

Participants

Inclusion criteria - Patient over 18 years of age; - Patient with a suspected SARS-CoV-2 infection, whether or not confirmed by PCR, or close contact with a PCR-confirmed case, typical chest CT scan (unsystema

SUBMITTER: Daval M 

PROVIDER: S-EPMC7370627 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature