Characterization of Neoantigen Load Subgroups in Gynecologic and Breast Cancers.

ABSTRACT:

Objective

Although gynecologic and breast (Pan-Gyn) cancers share a variety of similar characteristics, their response to immunotherapy is different. Immune checkpoint inhibitor therapy is not effective in all patients, while neoantigen load (NAL) may be a predictive biomarker. However, the selection of a NAL cutoff point and its predictive effect remain to be elucidated.

Methods

We divided 812 Pan-Gyn cancer samples from The Cancer Genome Atlas into three groups based on 60 and 80% of their load percentile. We then correlated the identified NAL subgroups with gene expression, somatic mutation, DNA methylation, and clinicopathological information. We also characterized each subgroup by distinct immune cell enrichment, PD-1 signaling, and cytolytic activity. Finally, we predi

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC7370692 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature