Mosaic representations of odors in the input and output layers of the mouse olfactory bulb.

ABSTRACT: The elementary stimulus features encoded by the olfactory system remain poorly understood. We examined the relationship between 1,666 physical-chemical descriptors of odors and the activity of olfactory bulb inputs and outputs in awake mice. Glomerular and mitral and tufted cell responses were sparse and locally heterogeneous, with only a weak dependence of their positions on physical-chemical properties. Odor features represented by ensembles of mitral and tufted cells were overlapping but distinct from those represented in glomeruli, which is consistent with an extensive interplay between feedforward and feedback inputs to the bulb. This reformatting was well described as a rotation in odor space. The physical-chemical descriptors accounted for a small fraction in response variance, and

SUBMITTER: Chae H 

PROVIDER: S-EPMC7370853 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature