Paternal age in rhesus macaques is positively associated with germline mutation accumulation but not with measures of offspring sociability.

ABSTRACT: Mutation is the ultimate source of all genetic novelty and the cause of heritable genetic disorders. Mutational burden has been linked to complex disease, including neurodevelopmental disorders such as schizophrenia and autism. The rate of mutation is a fundamental genomic parameter and direct estimates of this parameter have been enabled by accurate comparisons of whole-genome sequences between parents and offspring. Studies in humans have revealed that the paternal age at conception explains most of the variation in mutation rate: Each additional year of paternal age in humans leads to approximately 1.5 additional inherited mutations. Here, we present an estimate of the de novo mutation rate in the rhesus macaque (Macaca mulatta) using whole-genome sequence data from 32 individual

SUBMITTER: Wang RJ 

PROVIDER: S-EPMC7370888 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature