Wear particles induce a new macrophage phenotype with the potential to accelerate material corrosion within total hip replacement interfaces.

ABSTRACT: Evidence that macrophages can play a role in accelerating corrosion in CoCrMo alloy in total hip replacement (THR) interfaces leads to questions regarding the underlying cellular mechanisms and immunological responses. Hence, we evaluated the role of macrophages in corrosion processes using the cell culture supernatant from different conditions and the effect of wear particles on macrophage dynamics. Monocytes were exposed to CoCrMo wear particles and their effect on macrophage differentiation was investigated by comparisons with M1 and M2 macrophage differentiation. Corrosion associated macrophages (M_CA macrophages) exhibited upregulation of TNF-α, iNOS, STAT-6, and PPARG and down-regulation of CD86 and ARG, when compared to M1 and M2 macrophages. M_CA cells also secr

SUBMITTER: Bijukumar DR 

PROVIDER: S-EPMC7370988 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature