Identification of Gene Modules and Hub Genes Involved in Mastitis Development Using a Systems Biology Approach.

ABSTRACT:

Objective

Mastitis is defined as the inflammation of the mammary gland, which impact directly on the production performance and welfare of dairy cattle. Since, mastitis is a multifactorial complex disease and the molecular pathways underlying this disorder have not been clearly understood yet, a system biology approach was used in this study to a better understanding of the molecular mechanisms behind mastitis.

Methods

Publicly available RNA-Seq data containing samples from milk of five infected and five healthy Holstein cows at five time points were retrieved. Gene Co-expression network analysis (WGCNA) approach and functional enrichment analysis were then applied with the aim to find the non-preserved module of genes that their connectivity were altered under infected cond

SUBMITTER: Bakhtiarizadeh MR 

PROVIDER: S-EPMC7371005 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature