The small molecule CLP257 does not modify activity of the K+-Cl- co-transporter KCC2 but does potentiate GABAA receptor activity.
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ABSTRACT:
SUBMITTER: Cardarelli RA
PROVIDER: S-EPMC7371006 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
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The small molecule CLP257 does not modify activity of the K<sup>+</sup>-Cl<sup>-</sup> co-transporter KCC2 but does potentiate GABA<sub>A</sub> receptor activity.
Cardarelli Ross A RA Jones Karen K Pisella Lucie I LI Wobst Heike J HJ McWilliams Lisa J LJ Sharpe Paul M PM Burnham Matthew P MP Baker David J DJ Chudotvorova Ilona I Guyot Justine J Silayeva Liliya L Morrow Danielle H DH Dekker Niek N Zicha Stephen S Davies Paul A PA Holenz Jörg J Duggan Mark E ME Dunlop John J Mather Robert J RJ Wang Qi Q Medina Igor I Brandon Nicholas J NJ Deeb Tarek Z TZ Moss Stephen J SJ
Nature medicine 20171201 12
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