Molecular characterization of hepatitis A virus circulating in Uttar Pradesh, India: A hospital-based study.

ABSTRACT:

Background & objectives

Hepatitis A is prevalent worldwide and is among the leading cause of acute viral hepatitis in India. Major geographical differences in endemicity of hepatitis A are closely related to hygienic and sanitary conditions and other indicators of the level of socio-economic development. The present study was aimed to know the seropositivity prevalence and predominant circulating strain of HAV in a north India.

Methods

Patients with acute viral hepatitis were enrolled. Blood samples were collected over a period of one year from June 2016 to May 2017. Serum samples were tested for anti-immunoglobulin M (IgM) HAV antibodies. The seropositive samples were analyzed for HAV-RNA by real-time reverse transcription-polymerase chain reaction (RT-PCR). Samples detecte

SUBMITTER: Prakash S 

PROVIDER: S-EPMC7371058 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature