Duplication and diversification of a unique chromosomal virulence island hosting the subtilase cytotoxin in Escherichia coli ST58.

ABSTRACT: The AB₅ cytotoxins are important virulence factors in Escherichia coli. The most notable members of the AB₅ toxin families include Shiga toxin families 1 (Stx₁) and 2 (Stx₂), which are associated with enterohaemorrhagic E. coli infections causing haemolytic uraemic syndrome and haemorrhagic colitis. The subAB toxins are the newest and least well understood members of the AB₅ toxin gene family. The subtilase toxin genes are divided into a plasmid-based variant, subAB1, originally described in enterohaemorrhagic E. coli O113:H21, and distinct chromosomal variants, subAB2, that reside in pathogenicity islands encoding additional virulence effectors. Previously we identified a chromosomal subAB2 op

SUBMITTER: Wyrsch ER 

PROVIDER: S-EPMC7371111 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature