Plasmodium vivax AMA1: Implications of distinct haplotypes for immune response.

ABSTRACT: In Brazil, Plasmodium vivax infection accounts for around 80% of malaria cases. This infection has a substantial impact on the productivity of the local population as the course of the disease is usually prolonged and the development of acquired immunity in endemic areas takes several years. The recent emergence of drug-resistant strains has intensified research on alternative control methods such as vaccines. There is currently no effective available vaccine against malaria; however, numerous candidates have been studied in the past several years. One of the leading candidates is apical membrane antigen 1 (AMA1). This protein is involved in the invasion of Apicomplexa parasites into host cells, participating in the formation of a moving junction. Understanding how the genetic diversity of

SUBMITTER: Bittencourt NC 

PROVIDER: S-EPMC7371208 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature