Walking-related digital mobility outcomes as clinical trial endpoint measures: protocol for a scoping review.

ABSTRACT:

Introduction

Advances in wearable sensor technology now enable frequent, objective monitoring of real-world walking. Walking-related digital mobility outcomes (DMOs), such as real-world walking speed, have the potential to be more sensitive to mobility changes than traditional clinical assessments. However, it is not yet clear which DMOs are most suitable for formal validation. In this review, we will explore the evidence on discriminant ability, construct validity, prognostic value and responsiveness of walking-related DMOs in four disease areas: Parkinson's disease, multiple sclerosis, chronic obstructive pulmonary disease and proximal femoral fracture.

Methods and analysis

Arksey and O'Malley's methodological framework for scoping reviews will guide study conduct. We will

SUBMITTER: Polhemus AM 

PROVIDER: S-EPMC7371223 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature