Updates in trichomonas treatment including persistent infection and 5-nitroimidazole hypersensitivity.

ABSTRACT:

Purpose of review

The purpose of this review is to update information on treatment of Trichomonas vaginalis. T. vaginalis is estimated to be the most common treatable sexually transmitted infection. In the world and is associated with poor birth outcomes, cervical cancer, sperm motility and morphology issues, and HIV acquisition and transmission.

Recent findings

The efficacy of the recommended 2-g oral single-dose metronidazole (MTZ) for the treatment of T. vaginalis in women has recently been challenged. Two recent multicentered randomized trials and a meta-analysis have demonstrated that the 7-day dose of MTZ 500 mg twice daily was nearly two times more efficacious at clearing infection compared with the 2-g dose. Partner treatment is also essential, since up to 70% of mal

SUBMITTER: Muzny CA 

PROVIDER: S-EPMC7371247 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature