ATN classification and clinical progression in subjective cognitive decline: The SCIENCe project.

ABSTRACT:

Objective

To investigate the relationship between the ATN classification system (amyloid, tau, neurodegeneration) and risk of dementia and cognitive decline in individuals with subjective cognitive decline (SCD).

Methods

We classified 693 participants with SCD (60 ± 9 years, 41% women, Mini-Mental State Examination score 28 ± 2) from the Amsterdam Dementia Cohort and Subjective Cognitive Impairment Cohort (SCIENCe) project according to the ATN model, as determined by amyloid PET or CSF β-amyloid (A), CSF p-tau (T), and MRI-based medial temporal lobe atrophy (N). All underwent extensive neuropsychological assessment. For 342 participants, follow-up was available (3 ± 2 years). As a control population, we included 124 participants without SCD.

Results

Fifty-six (n = 385

SUBMITTER: Ebenau JL 

PROVIDER: S-EPMC7371376 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature