Clinical and pathologic features of cognitive-predominant corticobasal degeneration.

ABSTRACT:

Objective

To describe clinical and pathologic characteristics of corticobasal degeneration (CBD) with cognitive predominant problems during the disease course.

Methods

In a series of autopsy-confirmed cases of CBD, we identified patients with cognitive rather than motor predominant features (CBD-Cog), including 5 patients thought to have Alzheimer disease (AD) and 10 patients thought to have behavioral variant frontotemporal dementia (FTD). We compared clinical and pathologic features of CBD-Cog with those from a series of 31 patients with corticobasal syndrome (CBD-CBS). For pathologic comparisons between CBD-Cog and CBD-CBS, we used semiquantitative scoring of neuronal and glial lesion types in multiple brain regions and quantitative assessments of tau burden from image an

SUBMITTER: Sakae N 

PROVIDER: S-EPMC7371382 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature