Concentrations of persistent organic pollutants in maternal plasma and epigenome-wide placental DNA methylation.

ABSTRACT:

Background

Prenatal maternal plasma persistent organic pollutant (POP) concentrations have been associated with neonatal outcomes. However, the underlying mechanisms remain unknown. Placental epigenetic mechanisms may be involved, but no prior epigenome-wide studies have investigated the impact of maternal POPs on placental DNA methylation. We studied the association between maternal plasma POP concentration in early pregnancy and epigenome-wide placental DNA methylation among 260 pregnant women from the NICHD Fetal Growth Studies.

Results

Our analysis focused on POPs with more than 80% plasma concentrations above the limit of quantification, including 3 organochlorine pesticides (hexachlorobenzene, trans-nonachlor, p,p'-dichlorodiphenyldichloroethylene), 1 polybrominated di

SUBMITTER: Ouidir M 

PROVIDER: S-EPMC7371466 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature