Causal relationships between NAFLD, T2D and obesity have implications for disease subphenotyping.

ABSTRACT:

Background & aims

Non-alcoholic fatty liver disease (NAFLD), type 2 diabetes (T2D) and obesity are epidemiologically correlated with each other but the causal inter-relationships between them remain incompletely understood. We aimed to explore the causal relationships between the 3 diseases.

Methods

Using both UK Biobank and publicly available genome-wide association study data, we performed a 2-sample bidirectional Mendelian randomization analysis to test the causal inter-relationships between NAFLD, T2D, and obesity. Transgenic mice expressing the human PNPLA3-I148M isoforms (TghPNPLA3-I148M) were used as an example to validate causal effects and explore underlying mechanisms.

Results

Genetically driven NAFLD significantly increased the risk of T2D and central obesi

SUBMITTER: Liu Z 

PROVIDER: S-EPMC7371536 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature