Impulsiveness as a moderator of amphetamine treatment response for cocaine use disorder among ADHD patients.

ABSTRACT:

Background

Amphetamines are a first-line treatment for ADHD and have shown promise for the treatment of cocaine use disorder (CUD), both alone and with comorbid ADHD. Impulsiveness is a key aspect of both ADHD and substance use disorders. We sought to understand the role of baseline impulsiveness in the treatment of comorbid CUD and ADHD.

Methods

In a post hoc analysis (N = 76) of a 14-week, double-blind, randomized, placebo-controlled trial of mixed amphetamine salts-extended release (MAS-ER) for comorbid ADHD and CUD, we examined the relationship between treatment response and participants' baseline Barratt Impulsiveness Scale (BIS-11) score by comparing those with scores below versus above the median. In the original trial, participants received daily 60 mg MAS-ER, 80 mg 

SUBMITTER: Blevins D 

PROVIDER: S-EPMC7371538 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature