The impact of vitamin D supplementation on VDR gene expression and body composition in monozygotic twins: randomized controlled trial.

ABSTRACT: Vitamin D supplementation is widely used. However, there is no consensus on the use and dosage of this supplement and the existing recommendations arise from studies based on the benefits that this nutrient can facilitate in bones. In addition, individual genetics can influence the response to supplementation, therefore, research involving monozygotic twins aims to reduce these differences in phenotypic responses. The objective of this randomised controlled study is to examine the effect of vitamin D supplementation on body composition and the expression of the vitamin D receptor (VDR) mRNA. An intervention was performed through supplementation with cholecalciferol at the concentration of 2000 IU in 90 healthy adult monozygotic twins (male or female pairs) for 2 months. The findings showed

SUBMITTER: Medeiros JFP 

PROVIDER: S-EPMC7371728 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature