Alox12/15 Deficiency Exacerbates, While Lipoxin A₄ Ameliorates Hepatic Inflammation in Murine Alcoholic Hepatitis.

ABSTRACT: Alcoholism is one of the leading and increasingly prevalent reasons of liver associated morbidity and mortality worldwide. Alcoholic hepatitis (AH) constitutes a severe disease with currently no satisfying treatment options. Lipoxin A₄ (LXA₄), a 15-lipoxygenase (ALOX15)-dependent lipid mediator involved in resolution of inflammation, showed promising pre-clinical results in the therapy of several inflammatory diseases. Since inflammation is a main driver of disease progression in alcoholic hepatitis, we investigated the impact of endogenous ALOX15-dependent lipid mediators and exogenously applied LXA₄ on AH development. A mouse model for alcoholic steatohepatitis (NIAAA model) was tested in Alox12/15^+/+ and Alox12/15^-/- mice, with or w

SUBMITTER: Queck A 

PROVIDER: S-EPMC7371948 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature