Stroke and Alzheimer's Disease: A Mendelian Randomization Study.

ABSTRACT: Stroke and Alzheimer's disease (AD) are common neurological diseases. Several exiting studies indicated that late onset-AD and ischemic stroke have shared genetic links. Different kinds of stroke have different mechanisms. However, it remains unclear whether there is a causal relationship between different types of strokes, including any stroke (AS), any ischemic stroke (AIS), large-artery atherosclerotic stroke (LAS), and cardio-embolic stroke (CES), and AD. Herein, we conducted several Mendelian randomization (MR) studies to explore genetically causal link of different kinds of strokes and AD. The results for inverse-variance weighted (IVW) meta-analysis (β = -0.039, OR = 0.9618, and P-value = 0.750) and weighted median regression (WMR) (β = -0.156, OR = 0.8556, and P-value

SUBMITTER: Wang T 

PROVIDER: S-EPMC7371994 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature