Rapid HIV Progression Is Associated with Extensive Ongoing Somatic Hypermutation.

ABSTRACT: The Ab response to HIV is of great interest, particularly in the context of a protective vaccine and broadly neutralizing Abs, but research is typically geared toward elite controllers because of their ability to successfully control the virus. In this study, we studied the evolution of the Ab repertoire over the first year of HIV infection in people classified as rapid progressors (RP) compared with typical progressors. HIV RPs are an important yet understudied group of HIV patients classified by a rapid decline in CD4 counts and accelerated development of AIDS. We found that the global IgG somatic hypermutation load negatively correlated with disease progression, possibly because of exaggerated isotype switching of unmutated sequences in patients with low CD4 counts. We measured Ab seque

SUBMITTER: Wendel BS 

PROVIDER: S-EPMC7372316 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature