Anti-PfGARP activates programmed cell death of parasites and reduces severe malaria.

ABSTRACT: Malaria caused by Plasmodium falciparum remains the leading single-agent cause of mortality in children¹, yet the promise of an effective vaccine has not been fulfilled. Here, using our previously described differential screening method to analyse the proteome of blood-stage P. falciparum parasites², we identify P. falciparum glutamic-acid-rich protein (PfGARP) as a parasite antigen that is recognized by antibodies in the plasma of children who are relatively resistant-but not those who are susceptible-to malaria caused by P. falciparum. PfGARP is a parasite antigen of 80 kDa that is expressed on the exofacial surface of erythrocytes infected by early-to-late-trophozoite-stage parasites. We demonstrate that antibodies against PfGARP kill trophozoite-infected erythrocy

SUBMITTER: Raj DK 

PROVIDER: S-EPMC7372601 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature