Transcriptomic analysis on the effects of melatonin in gastrointestinal carcinomas.

ABSTRACT:

Background

Melatonin has been shown with anticancer property and therapeutic potential for tumors. However, there lacks a systematic study on the molecular pathways of melatonin and its antitumor effects in gastrointestinal carcinomas.

Methods

Using the gene expression profiles of four cancer cell lines from three types of gastrointestinal carcinomas before and after melatonin treatment, including gastric carcinoma (GC), colorectal carcinoma (CRC) and hepatocellular carcinoma (HCC), differentially expressed genes (DEGs) and biological pathways influenced by melatonin were identified. The qRT-PCR analyses were performed to validate the effects of melatonin on 5-FU resistance-related genes in CRC.

Results

There were 17 pathways commonly altered by melatonin in the three

SUBMITTER: Ao L 

PROVIDER: S-EPMC7372748 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature