Predicting DNA binding protein-drug interactions based on network similarity.

ABSTRACT:

Background

The study of DNA binding protein (DBP)-drug interactions can open a breakthrough for the treatment of genetic diseases and cancers. Currently, network-based methods are widely used for protein-drug interaction prediction, and many hidden relationships can be found through network analysis. We proposed a DCA (drug-cluster association) model for predicting DBP-drug interactions. The clusters are some similarities in the drug-binding site trimmers with their physicochemical properties. First, DBPs-drug binding sites are extracted from scPDB database. Second, each binding site is represented as a trimer which is obtained by sliding the window in the binding sites. Third, the trimers are clustered based on the physicochemical properties. Fourth, we build the network by genera

SUBMITTER: Wang W 

PROVIDER: S-EPMC7372772 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature