DCK is a promising prognostic biomarker and correlated with immune infiltrates in hepatocellular carcinoma.

ABSTRACT:

Background

Deoxycytidine kinase (DCK), an enzyme in the nucleoside biosynthetic pathway, can affect the development of immune cells. However, the relationships between the expression of DCK, patient prognosis, and tumor-infiltrating immune cells (TIICs) in hepatocellular carcinoma (HCC) are still unclear.

Methods

The expression of DCK in HCC was analyzed through the Oncomine and Tumor Immune Estimation Resource (TIMER) databases. The impact of DCK on clinical prognosis was investigated via the Kaplan-Meier plotter and verified in the Gene Expression Profiling Interactive Analysis (GEPIA) databases. The interrelationships between DCK expression and TIICs in HCC were analyzed by the TIMER database. Additionally, the relationship between DCK expression and immune cell gene mark

SUBMITTER: Song D 

PROVIDER: S-EPMC7372783 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature